Unaltered dopamine transporter availability in adult attention deficit hyperactivity disorder.

Long-Term Stimulant Treatment Affects Brain Dopamine Transporter Level in Patients with Attention Deficit Hyperactive Disorder

OBJECTIVE Brain dopamine dysfunction in attention deficit/hyperactivity disorder (ADHD) could explain why stimulant medications, which increase dopamine signaling, are therapeutically beneficial. However while the acute increases in dopamine induced by stimulant medications have been associated with symptom improvement in ADHD the chronic effects have not been investigated. METHOD We used pos...

ADHD in adolescence and adulthood, with a special focus on the dopamine transporter and nicotine

The persistence of attention deficit hyperactivity disorder (ADHD) into adolescence and adulthood has now been accepted as a clinical entity. The rate of prevalence among adults is assumed to be from 2% to 4%. With increasing age, a symptom change has to be considered; disturbance of attention becomes more prominent, whereas hyperactivity often diminishes or changes to inactivity. Neuroimaging ...

Prevalence of Attention Deficit Hyperactivity Disorder in Adults Hospitalized in Toxicology Ward of Mashhad University of Medical Sciences with Alcohol Poisoning

Background: Attention Deficit Hyperactivity Disorder (ADHD) is a common psychiatric disorder among children and adolescents that can be continued into adulthood in 30 to 50% of cases. Adult ADHD disorder can affect the performance of an individual and may predispose to drug abuse, alcoholism, smoking, sexual offenses, violation of law, educational and other social problems. The coincidences of ...

“Dopamine Transporter Knockout Mice: What Does This Model Tell Us About the Causes and Treatment of Attention Deficit Hyperactivity Disorder?”

A positron emission tomography study of nigro-striatal dopaminergic mechanisms underlying attention: implications for ADHD and its treatment

Through the combined use of (18)F-fallypride positron emission tomography and magnetic resonance imaging this study examined the neural mechanisms underlying the attentional deficits associated with attention deficit/hyperactivity disorder and their potential reversal with a single therapeutic dose of methylphenidate. Sixteen adult patients with attention deficit/hyperactivity disorder and 16 m...